- For the coach bus variant, see Coach.
The City Bus is based on the vast majority of buses that are operated by the real-life San Francisco Municipal Railway, using the same gray and red paint scheme. The vehicle comes with a small bicycle rack on the front and LED signs that read the location where the bus is found. For example, if the bus is in San Francisco, the LED sign will read "SAN FRANCISCO" (and Oakland and Silicon Valley, respectively.) The bus also bears two LCD screens on both sides, as well as a third one on the rear.
City buses mainly spawn in denser areas such as downtown San Francisco and Oakland, but spawn less frequently in suburban areas.
The performance of the vehicle is very similar to that of the Coach Bus, having low speed and acceleration, but average handling. Its brute force means it can pass through small cars easily, but the windows do not provide enough protection against gunfire.
- The rear fascia of the City Bus is very similar to the Bus in Driver: San Francisco, the previous major installment by Ubisoft. Also, like the Coach, the Bus' engine sound is very similar to that of buses and trucks in the aforementioned game.